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Recommended articles Optimising GLP-1RA Efficacy: A Meta-Analysis of Baseline Age and HbA1c as Predictors of MACE Reduction in T2DM Ghosal S, Ghosal A Diabetes, Metabolic Syndrome and Obesity 2025, 18:4347-4358 Published Date: 26 November 2025 Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Study Hwang I, Lee SW, Kim Y Drug Design, Development and Therapy 2026, 20:604247 Published Date: 14 July 2026

These findings have made the peptide relevant for laboratory work focused on energy storage, fat redistribution, and endocrine control of metabolic flux across tissues [1][2][5]

A phase 3 study conducted on patients with T2DM has shown that tirzepatide improves HbA1c levels at all doses (515 mg)

DOI: 10.1038/s12276-018-0084-3 [Google Scholar] Chang JT, Liang YJ, Hsu CY, Chen CY, Chen PJ, Yang YF, et al