Gaetano Morelli, Chief Medical Officer at Altasciences, noted: "As we learn more about GLP-1 RAs, we realize that they target many organ systems, including the pancreas, stomach, brain, heart, kidneys, immune system (due to reduced inflammation), skeletal muscle, and control of white and brown adipose tissue metabolism, with positive effects in fatty liver disease." Because these drugs address multiple chronic conditions simultaneously, they warrant broader clinical use
This is one theoretical explanation for why dose escalation sometimes produces diminishing returns
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However, abnormalities in the structure and function of the hippocampus and prefrontal cortex can cause cognitive impairment