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At the translational level, interventions targeting amino acid metabolism have the advantage of simultaneously affecting multiple inflammatory pathways, but their clinical application still faces challenges such as systemic side effects and insufficient tissue specificity

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An evaluation of the stability and pharmacokinetics of R-Lipoic acid and R-Dihydrolipoic acid dosage forms in human plasma from healthy subjects

If the ELF score is below this threshold and there are no other concerns, reassessment is recommended every three years