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Nrf2 is released from the Nrf2Keap1 system and then translocates to the cell nucleus, where it combines with small musculoaponeurotic fibrosarcoma (sMAF) proteins to form heterodimers

[16] Targeted disruption of the mitochondrial GPX4 isoform (mGPX4) caused infertility in male mice and disruption of the nuclear GPX4 isoform (nGPX4) reduced the structural stability of sperm chromatin, yet both knockout mouse models (for mGPX4 and nGPX4) were fully viable

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That prevalence alone makes any compound with pre-clinical gastroprotective properties worth examining in equine contexts