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The elevated homocysteine creates further oxidative stress and neuroinflammation, which in turn damages the myelin sheath and worsens the cognitive dysfunction and neuropathy
Wilson-Perez et al., 2013), a phenotype that goes against the role of GLP-1R signaling in the control of body weight
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Overall, this study shows that replacing four consecutives amino acid residues with an ureido triad of similar dimension and geometry in a peptide -helix is a good strategy to improve its pharmaceutical properties
(PubMed) Byun E, Lim JW, Kim JM, Kim H
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