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Wu J, Zhao Y, Fan Z, Chen Q, Chen J, Sun Y, et al

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Beyond these canonical targets, v3 integrin overexpression on tumor neo-vasculature and invasive cancer cells enables cRGD peptide-mediated dual targeting of angiogenesis and tumor survival, while nucleolin, aberrantly surface-displayed in proliferating breast cancer cells, offers aptamer-based (AS1411) recognition independent of traditional receptor-ligand paradigms [127]