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Five of the DPP-4 inhibitors (sitagliptin, vildagliptin, alogliptin, saxagliptin and linagliptin) were approved by regulatory authorities and entered the market between 2006 and 2013

Current evidence quality : Most berberine studies are relatively small, short-term (typically 816 weeks), and conducted primarily in Asian populations, which may limit generalisability

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Furthermore, MELODI Presto 41 highlighted a similar mediation pathway by mining literature evidence, wherein GLP-1R agonists modulated obesity-related factors that contributed to the risk of ENOC (Supplementary Data 20)

The medication was secure inside its small box, but the overall design prioritized branding over safe handling