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Further, NPs can be accumulated in the spleen, lymph nodes, and liver by the reticuloendothelial system [391]

Replace direct comparison language with: How does this compound differ from direct hormone administration models? The answer should state that CJC-1295 / Ipamorelin is studied for upstream receptor pathway research peptide behavior rather than direct hormone replacement

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European Journal of Pharmacology, 873, 172974

This concept of "biased agonism" is central to understanding why structurally similar compounds acting on the same receptor can produce different downstream effects