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[1] Because it is a large-protein biologic, evolocumab is not metabolized by the cytochrome P450 enzyme family

Bellia F, Lanza V, Naletova I, Tomasello B, Ciaffaglione V, Greco V, Sciuto S, Amico P, Inturri R, Vaccaro S, Campagna T, Attanasio F, Tabb G, Rizzarelli E (2023) Copper(II) complexes with carnosine conjugates of hyaluronic acids at different dipeptide loading percentages behave as multiple SOD mimics and stimulate Nrf2 translocation and antioxidant response in in vitro inflammatory model

This represents a gap in the evidence base that researchers should acknowledge when making decisions about protocol adoption

Stupnisek et al., 2015