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Prevalence in the US is 1:200 to 1:500 for homozygous mutations, seen mostly in Caucasians (highest in Scandinavian or Irish descent, lowest in African descent)

Clinical data shows the combination produces significantly greater weight loss than either agent alone

In addition, some authors investigated the risk associated with serum UA levels in a large cohort of patients with tauopathies (including subgroups with progressive supranuclear palsy, AD, and frontotemporal dementia) [222]