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What happened was rather remarkable, the placebo arm lost nearly 20% of their body weight in just SIX MONTHS

Chambers JC, McGregor A, Jean-Marie J, Obeid OA, and Kooner JS (1999a)

Expert Perspective Across two decades of real-world data, combining metformin with GLP-1 RAs consistently seems safer than either agent alone, a finding that is reassuring to clinicians and supports informed routine clinical decision-making in the evolving gluco-metabolic therapeutic landscape

The statistics back up that perception