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Eur J Biochem 190(3):445462 Rajaram S, Baylink DJ, Mohan S (1997) Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions

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Healthy aging is defined as the accumulation of time dependent cellular damage which factors include oxidative stress, epigenetic changes, genomic instability, telomere attrition, and dysregulation of cell signaling and inflammatory responses, upon further hit, this natural disruption may become detrimental [53]

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