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(Middle) Upon reaching the tumor site, these nanocarriers exert their therapeutic effects through three primary mechanisms (1): Macrophage Reprogramming, where the delivery of immunomodulators (e.g., TLR agonists) converts tumor-promoting, anti-inflammatory M2 macrophages into tumor-suppressive, pro-inflammatory M1 macrophages
Anti-inflammatory effect of glucagon like peptide-1 receptor agonist, exendin-4, through modulation of IB1/JIP1 expression and JNK signaling in stroke
Ard J, Fitch A, Fruh S, Herman L
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In clinical research, these pathways have been associated with reduced appetite, improved control of food intake, slower stomach emptying (which can increase fullness), and better blood sugar regulation
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