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A simplified framework is that its thought to occur when the intensity, frequency, and volume of Achilles tendon loading, such as during walking, running, or playing sports, exceeds your capacity to recover and adapt appropriately

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Ann Intern Med 104:427429 Kuffner EK, Dart RC, Bogdan GM, Hill RE, Casper E, Darton L (2001) Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial

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D., Bernier, M., Lpez-Lluch, G., & Navas, P