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Immunohistochemical staining and western blot analysis revealed that SNL increased the activation of microglia and astrocytes in the dentate gyrus of the hippocampus, along with elevated expression of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which were significantly reversed by exendin-4 treatment [68]
During the transition, doctors may recommend dosage adjustments based on factors like body weight, metabolic response, and tolerance to minimize side effects such as nausea or digestive discomfort
FDA status: Semaglutide is FDA-approved
PMC Lee, E., Park, H.-Y., Kim, S.-W
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