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PMID 21640828
It carries an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, giving it 83 amino acids total versus 70 for native IGF-1
Since glutathione is the major antioxidant in brain, modulation of its biosynthesis by withanolide A under hypoxic condition could ameliorate oxidative stress induced neurodegeneration and consequent memory dysfunction
These could be symptoms of low glutathione levels
T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T
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