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For a patient with obesity-related complications who needs treatment in 2026 or 2027, the practical answer to "Ozempic or retatrutide?" is: Ozempic, because retatrutide isn't available

Once that distinction is clear, the paradox disappears

SURMOUNT-5 participants who lost at least 5% of their body weight and had less than 5% weight change in the final 12 weeks of the study were invited to continue into the ATTAIN-MAINTAIN phase 3 trial, where participants were randomly assigned 3:2 to once-daily orforglipron (Foundayo, Eli Lilly) or placebo for 1 year

This is an important figure when constructing a tirzepatide 20mg dosage chart for in-vitro or in-vivo research models