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The triggers of cellular senescence include but are not limited to telomeric erosion, induction of the DNA damage response, epigenetic changes, genomic instability, mitochondrial dysfunction, reactive metabolites, oxidative stress, inactivation of certain tumor suppressor genes, oncogenic and therapy-induced stress, and viral infections (Narita et al., 2003

Science 362 (6418), 10641069

At 6 weeks post-operation, rats in both the 0.3 mg/ml and 3 mg/ml GHK-Cu treatment groups exhibited a significantly smaller side-to-side difference in A-P knee laxity compared to the saline group