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Moreover, pairing these medications with a balanced diet, healthy lifestyle, and regular physical activity is recommended for achieving the best outcomes

doi: 10.1093/femsre/fuy002 37

First, the expression of GLP-1R remains controversial in many types of cells and tissues due to the lack of specific antibody against GLP-1R

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This led to FDA approval of high dose semaglutide for weight loss in 2021