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Others use continuous protocols

Kang EA, Han Y-M, An JM, Park YJ, Sikiric P, Kim DH, et al

While the newly identified fragments did not significantly alter Tb TRs enzymatic activityconsistent with the nature of low-affinity ligandsthey provide valuable insights into key interactions of fragments with TR and, together with prior fragment screening campaigns, pave the way towards follow-up chemical optimization into lead compounds

This protective effect on brain cells is critical for patients suffering from traumatic brain injuries, as it can significantly improve their recovery outcomes