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If ongoing maintenance is necessary: Year 2: Compounded $2,388 vs Brand-name $11,628 (savings: $9,240) Year 3: Compounded $2,388 vs Brand-name $11,628 (savings: $9,240) Year 4: Compounded $2,388 vs Brand-name $11,628 (savings: $9,240) Year 5: Compounded $2,388 vs Brand-name $11,628 (savings: $9,240) 5-year total: Compounded $11,940 vs Brand-name $58,140 (savings: $46,200) For people requiring truly long-term treatment, the cumulative savings from compounded alternatives make ongoing medication financially feasible where brand-name costs would be prohibitive
It is complete loss of biological function
The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)
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What the Research Says In both studies, researchers tried to see if they could use machine learning models to correctly guess who would go on to have a bipolar disorder diagnosis based on their electronic medical records
