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Glucuronidation: UGTs catalyze an SN2 nucleophilic substitution where the substrate's nucleophilic functional group (OH, NH2, SH, COOH) attacks the C1 carbon of glucuronic acid in UDPGA, displacing UDP

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Patients should maintain adequate hydration, especially those with renal impairment, to reduce acute kidney injury risk associated with gastrointestinal side effects