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They are not medications and have not been approved to diagnose, treat, cure, or prevent any disease
The preclinical evidence: what the studies actually show Honest assessment of the evidence requires separating what has been demonstrated from what has been assumed
Here, we provide the first evidence of improved healthspan and age-related survival with a therapeutic mAb by demonstrating that treatment with an IGF-1R antagonist in older mice significantly and preferentially improves several indices of healthspan, reduced death from neoplastic disease, and increased mean and median lifespan in females
CD9 depletion synergized with ASCT2 inhibition to suppress PDAC organoid growth and prolong survival in KPC mice, highlighting the therapeutic potential of targeting the CD9ASCT2 axis
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