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Published Clinical Trial Data on GLP-1 Weight Loss Medications For patients comparing weight loss pills vs injections , clinical trial data provides important context

GLP-1 receptor agonists typically achieve 5-15% body weight reduction depending on the specific agent and dose, with semaglutide generally producing the greatest weight loss

Orlistat treatment should be continued beyond 12 weeks only if the person has lost at least 5% of their initial body weight

Callander N, Markovina S, Eickhoff J, et al

273 Considering the strong preclinical data on GLP-1 RAs in older animals, there is an urgent need for large-scale clinical studies to evaluate their safety and effectiveness in older populations