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FDA Review: The FDA reviews the NDA to determine whether the benefits of the drug outweigh its risks

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For example, a 2020 analysis found that an Oregon grape extract contained around 6mg of berberine per 1,000mg of plant material, suggesting that Oregons Wild Harvest delivers a little more than 6mg per serving.63 Thats a low dose, but Oregon grape contains other compounds that could help make up the difference