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These strain-dependent effects are primarily mediated through the engagement of specific pathogen-recognition receptors on DCs, including TLR2, TLR9, and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (165)
Following administration of ATX, there was a decrease in the level of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of DNA damage, and an increase in the expression of PARP1 (116 kDa) protein, which plays a role in facilitating DNA repair, in animals experiencing IS (18, 20)
10.1016/j.cell.2017.09.021 Cell 81 SugiyamaA.SunJ
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