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IGF-II also binds to the IGF-II receptor (also named the cation-independent mannose 6-phosphate receptor), which acts as a signaling antagonist to prevent IGF-II responses

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Once bound to the IGF-1 receptor 3 (IGF-1R), it triggers key anabolic pathways such as Akt/mTOR , stimulating protein synthesis, cellular growth, and repair

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