Mechanistic clinical studies with integrated immunophenotyping and multi-omics linked to immune response biomarkers (NK activity assays, T-cell clonality, cytokine panels, tumour immune infiltrate changes) GMP-formulated products (defined active components/valid potency) ( Figure 3 )
Senna is made from the pods of senna, or cassia, trees and is a source of plant chemicals called anthraquinones, which are the active component (Rama Reddy 2015
357,358 Thus, combinatorial strategies that block downstream pro-metastatic cytokines (e.g., IL-6 or CXCL8) or macrophage reprogramming may uncouple necroptosis from its deleterious consequences
Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, et al
This long-term view helps with budgeting and ordering