Data availability The atomic coordinates and the cryo-EM density maps generated during this study are available at the protein databank ( and the electron microscopy databank ( under accession numbers XXXX and XXXX, and EMDB entry ID EMD-XXXXX and ID EMD-XXXXX for the semaglutide and taspogltuide complexes, respectively
The other six patients gradually increased their dose, from 400 mg twice daily to 800 mg twice daily, over a one-month period
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ROR = 3.35, 95% CI 3.313.39) As illustrated in Fig