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Within the collectin family, surfactant protein A (SP-A) limits LPS-induced TLR4 signaling in alveolar macrophages via lysosomal degradation involving Rab7 and -arrestin2, highlighting its therapeutic potential in curbing excessive TLR4 activation [190]

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For invasive or sterile-use contexts, additional risks can include injection-site pain, bruising, infection, contamination-related events, and reactions to preservatives or other excipients

While doses of 3 grams (g) per day are considered safe, more study is needed to evaluate the role of lysine