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For example, chitosan oligosaccharide (COS)-dendritic polycarbonate (DPC) nanoparticles (CD NPs) can significantly activate TBK1/IRF3 phosphorylation, enhance STING signaling in macrophages and tumor cells, increase M1 TAMs and promote DCs maturation, reduce MDSCs and facilitate CD8 + T cells infiltration thereby reshaping the tumor microenvironment into a pro-inflammatory state (210)

Similarly, paeoniflorin mitigated periodontitis-associated systemic inflammation by restoring the Th17/Treg balance, suppressing the IL-6/STAT3/IL-17 pathway, and reversing gut microbial dysbiosis

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Start Low, Go Slow Begin with 250 mg per day