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PMID: 32825327

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However, three distinct lines of male mice deficient in leptin or leptin signaling, i.e., ob/ob , db/db and Lepr flox/flox;Emx1-Cre mice, exhibited different patterns of downregulation of exon-specific Bdnf gene expression, with ob/ob associated with decreased expression of exons II, III, IV, and VI, db/db associated with decreased expression of exons I, III, and IV and Lepr flox/flox;Emx1-Cre associated with decreased expression of exons I, II, IV, and VI

10,46 Additionally, it has been shown symptom improvement may not occur for three to six months after beginning treatment, a timeline which is not acceptable for many