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Studies in murine models indicate that IGF-1 LR3 may be cleared from the plasma faster, to be destributed more quickly into various tissue models as compared to IGF-1
112,113 In metastatic hormone receptorpositive breast cancer, mutations in the ligand-binding domain (LBD) of estrogen receptor 1 (ESR1), which encodes ER, contribute to treatment resistance
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Nat Clin Pract Nephrol
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