Canagliflozin has been trialed in a phase IIb study in overweight and obese subjects without T2D
However, a recent study screened for genes involved in peroxisome function through clustered regularly interspaced short palindromic repeats (CRISPR)-mediated promotion of ferroptosis via production of peroxisomal ether lipids, such as plasma proteins, rather than ROS or RNS, which are considered driving factors of ferroptosis and require involvement of peroxisome Fe (II) in this process (Zou et al
Thus, individualized regimens should be anticipated for groups with different metabolic profiles and clinical stages
They may not fully replace injectables, especially for patients requiring maximum weight reduction, but they could reshape early intervention, maintenance therapy, emerging market access, and primary care adoption
GHK-Cu works differently-its a non-hormonal topical peptide