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doi: 10.1210/JCEM.85.1.6306 142 BrilotFChehadehWCharlet-RenardCMartensHGeenenVHoberD

Reported Adverse Effects In the available case series and observational literature, the most commonly reported adverse effects include: Injection-site redness or mild induration in approximately 8 to 12% of users Transient nausea, most often associated with oral formulations or higher injectable doses Lightheadedness in a small number of patients shortly after injection (under 2% of reported cases) Vivid dreams or mild sleep changes, reported anecdotally by a subset of users with no clear mechanistic explanation No published human case reports as of July 2025 document serious organ toxicity, malignancy, or endocrine disruption attributable to BPC-157

In contrast, a recent and comprehensive meta-analysis reviewing 60 studies, which included 5981 individuals with either islet autoimmunity or T1D, did find a significant association between enteroviruses and cases of AAb+, established T1D, and recent onset T1D (199)

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