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The case underscores why reactions that are spreading or significantly changing in character are worth discussing with your healthcare provider rather than monitoring alone

This surface adsorption effect is more pronounced with lower peptide concentrations

Patients should be alert to: Persistent constipation , which may increase diverticular pressure New or worsening abdominal pain , especially if localised to the lower abdomen Changes in stool consistency or frequency Fever or systemic symptoms suggesting infection Communication with healthcare providers is vital

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For patients who are not well-controlled on a treatment with metformin and basal insulin, a treatment intensification with a DPP-4 inhibitor may be feasible