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The average frequency prior to treatment was 12 per day, which reduced to less than 8 per day after 1-2 weeks treatment
That's intentional
The strong before and after data is for tesamorelin alone, in HIV patients
CNS actions GLP-1R signaling plays a critical role in the maintenance of glucose homeostasis as deletion of the GLP-1R in mice results in impaired glucose tolerance (Scrocchi et al., In addition to this direct control of beta cells, GLP-1R signaling plays a role in the control of glucose homeostasis by regulating the activity of neurons both in the peripheral and central nervous system
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