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Participants began with a starting dose of 0.25 mg per week for both cagrilintide and semaglutide, with the doses co-escalated every four weeks (to 0.5 mg, 1.0 mg, and 1.7 mg) until reaching the maintenance dose of 2.4 mg per week for each medication after 16 weeks

10.1093/eurheartj/ehaa1103 Eur Heart J

These gastrointestinal issues are usually mild and tend to decrease over time as the body adjusts to the medication

Combined with targeted probiotics, my gut is the healthiest its been in a decade

You shouldn't skip it - it's the most important regulatory distinction in the entire category, and it became significantly more relevant following FDA enforcement action in early 2026