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Dasatinib has shown antifibrotic effects in keloid fibroblasts and xenotransplant keloid tissue in mice through the selective clearance of senescent cells and modulation of SASP, implying that dasatinib can be possibly used for senolytic treatment of keloids 15
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Animal studies have shown adverse fetal outcomes with GLP-1 agonists
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CagriSema is a fixed-dose combination therapy comprising two molecules administered together in a single once-weekly subcutaneous injection: semaglutide 2.4 mg, a glucagon-like peptide-1 (GLP-1) receptor agonist already approved for weight management as Wegovy, and cagrilintide 2.4 mg, a long-acting analogue of amylin, a hormone involved in appetite regulation and satiety signalling
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