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Most GLP-1 receptor agonists carry a boxed warning for thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

However, differences in sociodemographic profile and comorbidities were present, such as higher incomes and educational level of GLP-1 RAs users compared with SGLT-2 inhibitor users and DPP-4 inhibitor users suggesting selection bias in prescription