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Astrocytes surrounding degenerating motor neurons show increased expression of inflammatory markers, notably cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) [248]

Garcia-Bonilla L, Brea D, Benakis C, Lane DA, Murphy M, Moore J, et al

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Furthermore, weight loss outcomes were similar in participants who experienced gastrointestinal side effects compared to those who did not, proving that the medication works independently of side effects