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This cycling between cold and warm can cause crystallization and reduce the medication's ability to work properly
It is important to emphasize that any potential skin-related benefits would be secondary consequences of metabolic improvement rather than direct dermatologic effects
Clinical evidence suggests both agents produce nausea, vomiting, and constipation early in treatment
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Pharmacokinetic scaling across species rodent to larger animal to human extrapolation has not been rigorously published
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