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GLP-1-based treatment can be a meaningful option for eligible patients managing obesity, insulin resistance, type 2 diabetes, or weight-related health concerns

The use of claim 28 wherein the peptide Ac-Nle-cycVo(-Asp-His-D-Phe-Arg-Trp-Lys)- OH is employed for manufacture of a medicament for treatment by nasal administration and the PDE-5 inhibitor is employed for manufacture of a medicament for treatment by oral administration

They work by mimicking the GLP-1 hormone in the body that controls insulin and blood glucose levels, and their effects on the brain can reduce hunger, helping people feel full for longer