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doi: 10.3389/fimmu.2022.997578 Received 19 July 2022 Accepted 24 November 2022 Published 08 December 2022 Volume 13 - 2022 Edited by Jorg Hermann Fritz, McGill University, Canada Reviewed by Cristian Loretelli, University of Milan, Italy

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Our study describes a novel action of GLP-1 signalling in -cells, which stimulates metabolic/bioenergetic reprograming resulting in a high glycolytic/high ATP generating phenotype, as detailed in (Fig