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Nevertheless, CuP is prone to hydrolysis by proteases, resulting in treatment failure 34,37

However, whether gut microbiome dysbiosis acts as a trigger and modulator of autoimmune responses in the context of NIU, or is a consequence of inflammation-driven immune imbalance and metabolic alterations during disease progression, remains a subject of debate

Since natural glutathione production also decreases, there's little defense against the increase in oxidative stress

These data confirm that oxLDL loading of RAW264.7 Ms increases GSR abundance after LPS stimulation and thus justify the use of these conditions to validate our proposed assay