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Cardioprotection and lifespan extension by the natural polyamine spermidine
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Once phosphorylated, these transcription regulators could migrate into the nucleus of somatotroph cells, possibly impacting genes associated with growth hormone formation
These processes are central to the pathogenesis of a wide range of NDDs, including Alzheimers disease (AD), Parkinsons disease (PD), primary tauopathies (e.g., progressive supranuclear palsy [PSP], corticobasal degeneration [CBD], tau-linked frontotemporal dementia [FTD-tau]), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), synucleinopathies (e.g., Lewy body dementia [LBD] and multiple system atrophy [MSA]), Huntingtons disease (HD) and related polyglutamine (polyQ) diseases (e.g., spinocerebellar ataxias [SCA]), and prion diseases (PrD)
Steph put it in a way that hits home: If we truly viewed obesity as a chronic disease then bariatric surgery and GLP-1 medications are treatments, not tests you pass or fail. Steph Wagner Obesity is a chronic disease, and chronic disease needs lifelong treatment
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