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Visible degradation signals contamination and warrants discarding the bottle regardless of where in the 28-day window it sits

Feb 2005;6(1):15-22

(Also see our Top Picks among these products.) Clinical Update 10/02/2018 Probiotic for Abdominal Pain A probiotic was found to significantly reduce symptoms in people with acute diarrhea and abdominal pain, adding to the number of probiotics shown to have related effects

Lagares, C., et al., Maternal intake of alpha-lipoic acid prevents development of symptoms associated with a fructose-rich diet in the male offspring in Wistar rats