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(39) suggested that treating the underlying autonomic dysfunction reduces the number of vomiting episodes in CVS and many children can have a reduced number of vomiting episodes from fluid administrations, salt supplementation, fludrocortisone, and low-dose propranolol (82)
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To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs
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