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A unique form of the subunit, consisting of hCG- residues 640 with disulfide bond links to residues 5592, the core fragment accounts for as much as 90% of immunoreactive hCG- in urine during pregnancy.66, 67 Although the core fragment is a catabolite of hCG that is generated largely in the kidney, there is a possibility that some of this material originates from the placenta.68 In fact, placental macrophages may degrade hCG into nicked hCG and the core fragment, thereby preventing intact hCG from entering the fetal circulation and deranging the developing fetal endocrine system

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Obstet Gynecol 97: 464, 2001 88 Ren GS, Braunstein GD: Human chorionic gonadotropin