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Concurrent medications and conditions The presence of other medications or medical conditions can impact the subcutaneous absorption of tirzepatide: Vasoconstrictors: Medications that narrow blood vessels may slow absorption Vasodilators: Drugs that widen blood vessels could potentially increase absorption rates Edema: Fluid retention in tissues may impede absorption Diabetes-related complications: Conditions such as neuropathy or vascular disease can affect local blood flow and absorption Optimizing absorption for maximum efficacy To ensure that patients receive the full benefits of tirzepatide therapy, it's crucial to implement strategies that optimize subcutaneous absorption

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Wegovy is now the first weight-loss medication to also be approved to help prevent life-threatening cardiovascular events in adults with cardiovascular disease and either obesity or overweight, says John Sharretts, MD, director of the division of diabetes, lipid disorders, and obesity in the FDAs Center for Drug Evaluation and Research, in a release

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Then came SURMOUNT-1, in a 2022 follow-up study by NEJM , which tested tirzepatide (Mounjaro) in people with obesity